Journal: Molecules

Article Title: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

doi: 10.3390/molecules27082564

Figure Lengend Snippet: Natural Antioxidants.

Article Snippet: The paradigm of a multitarget therapy based on an association of different antioxidant molecules should be expected to improve the abrogation of oxidative damage and related effects derived from ROS burst, particularly occurring early at the onset of reperfusion.

Techniques: Activity Assay, Membrane, Activation Assay, Inhibition, Expressing

Journal: Molecules

Article Title: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

doi: 10.3390/molecules27082564

Figure Lengend Snippet: Synthetic antioxidants.

Article Snippet: The paradigm of a multitarget therapy based on an association of different antioxidant molecules should be expected to improve the abrogation of oxidative damage and related effects derived from ROS burst, particularly occurring early at the onset of reperfusion.

Techniques: Activation Assay, Activity Assay, Inhibition, Protein-Protein interactions, Binding Assay

Journal: Molecules

Article Title: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

doi: 10.3390/molecules27082564

Figure Lengend Snippet: Representation of resveratrol cardioprotective effect. Resveratrol activates the Nrf2 signaling pathway, increasing the expression of antioxidant enzymes. It also reduces the expression of pro-apoptotic proteins, such as caspase 3, via the PI3K/Akt pathway. Other effects are the reduction of inflammation and ferroptosis, which has been associated with reduced expression of TNFα, Nf κ B, TfR1, and increased activity of GPX4 after administration of resveratrol. The activation of SIRT1 is related to a decrease in intramitochondrial calcium concentration, which diminishes mitochondrial ROS production.

Article Snippet: The paradigm of a multitarget therapy based on an association of different antioxidant molecules should be expected to improve the abrogation of oxidative damage and related effects derived from ROS burst, particularly occurring early at the onset of reperfusion.

Techniques: Expressing, Activity Assay, Activation Assay, Concentration Assay

Journal: Molecules

Article Title: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin

doi: 10.3390/molecules27082564

Figure Lengend Snippet: Representation of quercetin cardioprotective effect. Quercetin acts through the inhibition of the enzymes xanthine oxidase, NADPH oxidase and the Fenton reaction, mechanisms leading to a decrease in ROS production. In addition, it acts by activating the selenoprotein TrxR2, which has a powerful antioxidant effect by inactivating ROS. All these mechanisms lead to a decrease in oxidative stress.

Article Snippet: The paradigm of a multitarget therapy based on an association of different antioxidant molecules should be expected to improve the abrogation of oxidative damage and related effects derived from ROS burst, particularly occurring early at the onset of reperfusion.

Techniques: Inhibition

Journal: International Journal of Molecular Sciences

Article Title: Perry Disease: Current Outlook and Advances in Drug Discovery Approach to Symptomatic Treatment

doi: 10.3390/ijms251910652

Figure Lengend Snippet: 5-HT 1A R pharmacophore screening results, including up to 10 hit molecules, excluding well-established medicines and pharmacological tools.

Article Snippet: The highest score value was calculated for H1 , developed in the study exploring multitarget 5-HT 1A R agonists and D 2 R, 5-HT 2A receptor (5-HT 2A R) antagonists as schizophrenia drug candidates by automated deep-learning workflow.

Techniques:

Journal: International Journal of Molecular Sciences

Article Title: Perry Disease: Current Outlook and Advances in Drug Discovery Approach to Symptomatic Treatment

doi: 10.3390/ijms251910652

Figure Lengend Snippet: Two most potent 5-HT 1A R agonists from a multitarget schizophrenia drug study [ 78 ].

Article Snippet: The highest score value was calculated for H1 , developed in the study exploring multitarget 5-HT 1A R agonists and D 2 R, 5-HT 2A receptor (5-HT 2A R) antagonists as schizophrenia drug candidates by automated deep-learning workflow.

Techniques: